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Washout Rate of Tc-99m Mibi in Bone and Soft-tissue Sarcomas: is It a Predictor of Tissue Necrosis Caused by Neoadjuvant Therapy? Muhammad Sohaib
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Washout Rate of Tc-99m Mibi in Bone and Soft-tissue Sarcomas: is It a Predictor of Tissue Necrosis Caused by Neoadjuvant Therapy?
Muhammad Sohaib
Neoadjuvant therapy is employed before the primary treatment of sarcomas. It is not uncommon that it fails due to multi-drug resistance gene causing unnecessary delays in surgery. Tc-99m MIBI, a radiopharmaceutical, is taken-up in these tumours. Being substrate of P-glycoprotein (Pgp), its washout from the malignant tissue may predict the response of sarcoma to neoadjuvant therapy. This book presents the author?s experience of in-vivo quantitative estimation of the washout rates of Tc-99m MIBI from nuclear medicine scans of various bone and soft-tissue sarcomas. These rates were then assessed for their ability to predict the effectiveness of neoadjuvant therapy initiated afterwards.
| Media | Books Paperback Book (Book with soft cover and glued back) |
| Released | July 28, 2014 |
| ISBN13 | 9783659580505 |
| Publishers | LAP LAMBERT Academic Publishing |
| Pages | 80 |
| Dimensions | 152 × 229 × 5 mm · 137 g |
| Language | German |
