Prokofiy Sklyuev

Imidazolidy 1-adamantankarbonovykh Kislot: Vzaimosvyaz' Struktury I Reaktsionnoy Sposobnosti Prokofiy Sklyuev Russian edition

Imidazolidy 1-adamantankarbonovykh kislot ? N-atsilazoly, sostoyashchie iz imidazola, svyazannogo po atomu azota s karbonil'nym atomom 1-adamantankarbonovoy kisloty. Dannye imidazolidy, kak i bol'shinstvo N-atsilazolov, reaktsionnosposobnye soedineniya, kotorye mogut byt' ispol'zovany v kachestve kondensiruyushchikh agentov, effektivnykh dlya polucheniya biologicheski aktivnykh veshchestv. Odnako svedeniya o reaktsionnoy sposobnosti podobnykh soedineniy, soderzhashchikh ob"emnyy adamantil'nyy fragment, v literature otsutstvuyut. V dannoy knige privoditsya sintez imidazolidov 1-adamantankarbonovykh kislot, issledovanie kinetiki ikh gidroliza i naibolee znachimye kriterii otsenki reaktsionnoy sposobnosti. V knige takzhe rassmatrivaetsya stroenie i reaktsionnaya sposobnost' N-atsilazolov i N, N?-atsilbisazolov v reaktsiyakh nukleofil'nogo prisoedineniya, dan obzor metodam sinteza etikh soedineniy, privedeny kolichestvennye dannye po ikh gidrolizu. Takzhe obsuzhdaetsya vozmozhnost' primeneniya v farmakologii soedineniy, poluchennykh s ispol'zovaniem imidazolidov 1-adamantankarbonovykh kislot i 6-zameshchennykh 1,3-benzotiazolaminov.