Metodologiya Lokus-spetsificheskogo Analiza Metilirovaniya Dnk: Genomnyy Podkhod - Ekaterina Kuznetsova - Books - LAP LAMBERT Academic Publishing - 9783659670411 - December 29, 2014
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Ekaterina Kuznetsova
Metodologiya Lokus-spetsificheskogo Analiza Metilirovaniya Dnk: Genomnyy Podkhod Russian edition

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Metilirovanie raspredeleno na protyazhenii CpG-ostrovkov genoma cheloveka neravnomerno i modifikatsiya razlichnykh CpG-dinukleotidov po-raznomu vliyaet na ekspressiyu genov. Pravil'nyy dizayn laboratornykh protokolov dlya opredeleniya metilirovaniya DNK mozhet osnovyvat'sya tol'ko na dostovernoy informatsii o strukturno?funktsional'noy organizatsii izuchaemykh C, G-bogatykh oblastey. Na segodnyashniy den' podobnaya informatsiya otsutstvuet dlya bol'shinstva, dazhe naibolee khorosho izuchennykh, genov, vovlechyennykh v kantserogenez. V svyazi s etim osoboe znachenie priobretaet podrobnaya individual'naya kharakteristika osobennostey genomnykh lokusov, differentsial'noe metilirovanie kotorykh assotsiirovano s razvitiem zlokachestvennykh novoobrazovaniy. V monografii opisany sovremennye podkhody k vyboru genomnykh lokusov dlya analiza differentsial'nogo metilirovaniya DNK i trebovaniya k dizaynu test-sistem, prednaznachennykh dlya lokus-spetsificheskogo analiza.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released December 29, 2014
ISBN13 9783659670411
Publishers LAP LAMBERT Academic Publishing
Pages 104
Dimensions 6 × 150 × 220 mm   ·   173 g
Language German  

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