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Role of Tcf in Body Axis Formation: Discovery of a Dual Action of Xtcf-3 in Xenopus Body Axis Formation Miranda Molenaar
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Role of Tcf in Body Axis Formation: Discovery of a Dual Action of Xtcf-3 in Xenopus Body Axis Formation
Miranda Molenaar
A novel role of TCF family in body axis formation. Revolutionary high impact discoveries are described, elucidating the missing link in the Wnt pathway and protein-TCF combinations with dual functions. By studying the primary axis formation of Xenopus laevis, it was firstly shown that, in combination with beta-catenin, TCF acts as a potent activator of proto-oncogenes. Secondly, it was discovered that in combination with the Groucho family of proteins, TCF acts as suppressor of oncogene transcription. Stronlgy suggesting that TCF controls oncogene transcription in a dual fashion. These discoveries contributed to the origination of a major area of cancer research and opened multiple angles for cancer therapy development.
| Media | Books Paperback Book (Book with soft cover and glued back) |
| Released | June 6, 2010 |
| ISBN13 | 9783838320526 |
| Publishers | LAP Lambert Academic Publishing |
| Pages | 80 |
| Dimensions | 225 × 5 × 150 mm · 137 g |
| Language | German |