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Kompleks I V Sostave Membrannykh Preparatov Mozga: Rol' Zhirnykh Kislot V Regulyatsii Aktivnosti Denis Kalashnikov Russian edition
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Kompleks I V Sostave Membrannykh Preparatov Mozga: Rol' Zhirnykh Kislot V Regulyatsii Aktivnosti
Denis Kalashnikov
Bol'shaya chast' svedeniy o kataliticheskikh svoystvakh mitokhondrial'noy NADH: ubikhinon oksidoreduktazy (kompleksa I) polucheno pri izuchenii razlichnykh preparatov serdechnoy myshtsy, togda kak o svoystvakh kompleksa I v mitokhondriyakh nervnoy tkani prakticheski nichego neizvestno. V rabote opisana protsedura polucheniya energeticheski sopryazhennykh invertirovannykh submitokhondrial'nykh chastits mozga. Pokazano, chto kharakteristiki kompleksa I mitokhondriy mozga, v chastnosti, parametry aktivatsii-deaktivatsii, malo otlichayutsya ot takovykh analogichnogo preparata serdechnoy myshtsy. Pokazano, chto endogennye ili dobavlennye svobodnye zhirnye kisloty vyzyvayut razvivayushcheesya vo vremeni ingibirovanie kompleksa I invertirovannykh submitokhondrial'nykh chastits mozga. Skorost' i stepen' ingibirovaniya uvelichivayutsya v prisutstvii ionov kal'tsiya. Kal'tsiy-zavisimoe ingibirovanie kompleksa I zhirnymi kislotami rN-zavisimo i naibolee vyrazheno pri shchelochnykh znacheniyakh pH, obrashchaetsya dobavleniem EGTA ili syvorotochnogo al'bumina. Syvorotochnyy al'bumin predotvrashchaet ingibirovanie perekhoda deaktivirovannoy formy kompleksa I ionami kal'tsiya pri shchelochnykh rN. Obsuzhdaetsya mekhanizm sovmestnogo deystviya zhirnoy kisloty i ionov kal'tsiya na kompleks I.
| Media | Books Paperback Book (Book with soft cover and glued back) |
| Released | July 17, 2011 |
| ISBN13 | 9783838378305 |
| Publishers | LAP LAMBERT Academic Publishing |
| Pages | 132 |
| Dimensions | 150 × 8 × 225 mm · 215 g |
| Language | German |