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Geterotsiklicheskie Analogi 5,12-naftatsenkhinona: Sintez, Khimicheskie Svoystva I Biologicheskaya Aktivnost' Andrey Shchekotikhin Russian edition
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Geterotsiklicheskie Analogi 5,12-naftatsenkhinona: Sintez, Khimicheskie Svoystva I Biologicheskaya Aktivnost'
Andrey Shchekotikhin
Rabota posvyashchena razrabotke metodologii sinteza biologicheski aktivnykh geterotsiklicheskikh analogov 5,12-naftatsenkhinona (lineynykh geteroarenantrakhinonov), soderzhashchikh v peri-polozheniyakh elektronodonornye zamestiteli, izucheniyu ikh fiziko-khimicheskikh svoystv i biologicheskoy aktivnosti. V ney opisany metody polucheniya i modifikatsii soedineniy, otnosyashchikhsya k 11 klassam geteroarenantrakhinonov. Pokazano vliyanie geterotsikla i khromofornykh grupp na spektral'nye svoystva geteroarenantrakhinonov. Opisan sintez i biologicheskie svoystva svyshe 150 proizvodnykh. V rezul'tate raboty v ryadu geteroarenantrakhinonov vyyavlen ryad zakonomernostey struktura-aktivnost' i polucheny soedineniya, sposobnye preodolevat' rezistentnost' opukholevykh kletok s razlichnymi mekhanizmami mnozhestvennoy lekarstvennoy ustoychivosti. Pokazano, chto antiproliferativnaya aktivnost' geterotsiklicheskikh analogov 5,12-naftatsenkhinona svyazana s ikh sposobnost'yu ingibirovat' fermenty, vazhnye dlya kletochnogo deleniya: topoizomerazu I, telomerazu i proteinkinazy. Rabota predstavlyaet interes dlya spetsialistov, rabotayushchikh v oblasti sinteticheskoy organicheskoy khimii, meditsinskoy khimii, khimii geterotsiklicheskikh soedineniy i krasiteley.
| Media | Books Paperback Book (Book with soft cover and glued back) |
| Released | June 14, 2011 |
| ISBN13 | 9783843324977 |
| Publishers | LAP LAMBERT Academic Publishing |
| Pages | 508 |
| Dimensions | 150 × 28 × 225 mm · 774 g |
| Language | German |