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Mekhanizm Peptid-oposredovannoy Belkovoy Transduktsii: Neselektivnye Peptid-lipidnye Pory Kak Model' Protsessa Belkovoy Transduktsii S Pomoshch'yu Kationnykh Analogov Gramitsidina a Sergey Koval'chuk Russian edition
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Mekhanizm Peptid-oposredovannoy Belkovoy Transduktsii: Neselektivnye Peptid-lipidnye Pory Kak Model' Protsessa Belkovoy Transduktsii S Pomoshch'yu Kationnykh Analogov Gramitsidina a
Sergey Koval'chuk
Odnim iz naibolee prostykh i effektivnykh podkhodov dlyadostavki v tsitoplazmu eukarioticheskikh kletok klyuchevykhbiomolekul (peptidy, belki, nukleinovye kisloty)yavlyaetsya ispol'zovanie nizkomolekulyarnykh, v chastnostipeptidnykh vektorov, obespechivayushchikh transmembrannyyperenos za schet formirovaniya vremennykh nekovalentnykhkompleksov. Dannaya rabota posvyashchena izucheniyumekhanizma protsessa belkovoy transduktsii,oposredovannoy kationnymi amfipatichnymi peptidami ?proizvodnymi prirodnogo antibiotika gramitsidina A. Rabota vklyuchaet detal'noe issledovanie vzaimodeystviyapeptidov s model'nymi membrannymi sistemami i stransportiruemymi belkami v rastvore. Krome togo, naserii napravlenno modifitsirovannykh peptidov izuchenatransduktsiya model'nogo belka beta-galaktozidazy veukarioticheskie kletki i proslezhena korrelyatsiyatransportnoy aktivnosti s povedeniem tekh zhe peptidovv iskusstvennykh membrannykh sistemakh. Poluchennyerezul'taty pozvolyayut rassmatrivat' formirovaniepeptid-lipidnykh por kak neobkhodimoe uslovie isushchestvennyy etap protsessa translokatsii nekovalentnykhpeptid-belkovykh kompleksov.
| Media | Books Paperback Book (Book with soft cover and glued back) |
| Released | July 14, 2011 |
| ISBN13 | 9783844358353 |
| Publishers | LAP LAMBERT Academic Publishing |
| Pages | 208 |
| Dimensions | 150 × 12 × 225 mm · 328 g |
| Language | German |