Osobennosti Rasshchepleniya Rnk Iskusstvennymi Ribonukleazami: Chto Takoe Iskusstvennye Ribonukleazy I Faktory, Opredelyayushchie Effektivnost' I Spetsifichnost' Ikh Deystviya - Nikolay Tamkovich - Books - LAP LAMBERT Academic Publishing - 9783844359701 - July 14, 2011
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Nikolay Tamkovich
Osobennosti Rasshchepleniya Rnk Iskusstvennymi Ribonukleazami: Chto Takoe Iskusstvennye Ribonukleazy I Faktory, Opredelyayushchie Effektivnost' I Spetsifichnost' Ikh Deystviya Russian edition

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RNK ? vazhneyshiy uchastnik bol'shinstva biokhimicheskikh protsessov. Razrabotka metodov napravlennogo vozdeystviya na RNK otkryvaet vozmozhnost' regulirovat' razlichnye kletochnye protsessy i inaktivirovat' genomy RNK-soderzhashchikh virusov. V poslednie gody v laboratoriyakh mira bylo polucheno bol'shoe chislo nizkomolekulyarnykh soedineniy, sposobnykh rasshcheplyat' RNK v fiziologicheskikh usloviyakh. Odnako na nastoyashchiy moment sushchestvuyushchie effektivnye khimicheskie ribonukleazy (aRNKazy) naydeny, preimushchestvenno, putyem skrininga soedineniy, a ne splanirovannogo sinteza. Rol' RNK, kak vtorogo uchastnika reaktsii rasshchepleniya izuchena ne polnost'yu. V nastoyashchey rabote v ramkakh literaturnogo obzora rassmotreny osnovnye printsipy stroeniya i funktsionirovaniya prirodnykh i iskusstvennykh ribonukleaz. Provedeno sistemnoe issledovanie funktsional'noy roli elementov struktury uzhe opisannykh iskusstvennykh ribonukleaz. Predstavleny rezul'taty issledovaniya novykh iskusstvennykh ribonukleaz, skonstruirovannykh na osnove peptidopodobnykh i gidrofobnykh fragmentov. Izucheno vliyanie odnonukleotidnykh zamen v lineynykh i strukturirovannykh RNK s gomologichnymi posledovatel'nostyami na ustoychivost' ikh k rasshchepleniyu iskusstvennoy ribonukleazoy.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released July 14, 2011
ISBN13 9783844359701
Publishers LAP LAMBERT Academic Publishing
Pages 180
Dimensions 150 × 10 × 225 mm   ·   286 g
Language German  

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