Kupffer Cell Depletion in the Scid-upa Chimeric Mouse Model - Ali Cadili - Books - LAP LAMBERT Academic Publishing - 9783844386783 - June 15, 2011
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Ali Cadili
Kupffer Cell Depletion in the Scid-upa Chimeric Mouse Model

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The SCID/uPA mouse model is a valuable tool for the study of human hepatic diseases and functions. This model may also shed light on the nature, and solutions to, xenograft rejection. The variability in the level of human chimerism achieved in this model warrants further investigation and improvement. Macrophage depletion may improve chimerism in this model. We hypothesized that Kupffer Cell (KC) depletion would enhance chimerism. Our results uncovered the dose efficacy and toxicity of clodronate liposomes in both adult SCID mice and neonatal SCID/uPA mice.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released June 15, 2011
ISBN13 9783844386783
Publishers LAP LAMBERT Academic Publishing
Pages 112
Dimensions 150 × 7 × 225 mm   ·   185 g
Language German  

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