Stanislav Naryzhnyy

Yadernyy Antigen Proliferiruyushchikh Kletok: Koordinator Kletochnykh Funktsiy: Belok, Proteom, Interaktom - Stupeni Sistemnoy Biologii Stanislav Naryzhnyy Russian edition

Sovremennye proteomnye tekhnologii vyyavili nalichie i vazhnuyu rol' mnogochislennykh belok-belkovykh vzaimodeystviy, tak nazyvaemogo interaktoma. Mekhanizmy ego funktsionirovaniya v bol'shoy stepeni opredelyayut zhiznennye protsessy vnutri kletki. Nekotorye belki imeyut osobuyu rol', otlichayutsya nalichiem bol'shogo kolichestva partnerov i yavlyayutsya ob"edinyayushchimi tsentrami (khabami) interaktoma. Odnim iz takikh khabov yavlyaetsya yadernyy antigen proliferiruyushchikh kletok (PCNA, proliferating cell nuclear antigen). Avtor monografii, analiziruya svoi i literaturnye dannye, opisyvaet mekhanizmy i stroit modeli funktsionirovaniya etogo belka. Obnaruzhennaya rol' PCNA kak koordinatora razlichnykh protsessov daet predstavlenie ne tol'ko ob otdel'no vzyatom belke, no i o fundamental'nykh aspektakh sistemnoy biologii, vzglyady na kotorye seychas tol'ko nachinayut formirovat'sya. Dan bogatyy fakticheskiy material i opisany raznoobraznye eksperimental'nye podkhody biokhimii i proteomiki. Kniga prednaznachena ne tol'ko dlya spetsialistov, no i dlya vsekh lyudey, interesuyushchikhsya dannoy oblast'yu. Mozhet sluzhit' khoroshim dopolnitel'nym uchebnikom dlya studentov, izuchayushchikh biokhimiyu, proteomiku i sistemnuyu biologiyu.