Mikhail Mandel'shtam

Semeynaya Giperkholesterinemiya I Semeynyy Rak Molochnoy Zhelezy: Molekulyarno-geneticheskoe Issledovanie Zhiteley Sankt-peterburga Mikhail Mandel'shtam Russian edition

Sredi serdechno-sosudistykh i onkologicheskikh zabolevaniy vydelyayutsya semeynye formy, pri kotorykh bolezn' razvivaetsya u neskol'kikh rodstvennikov i k tomu zhe v bolee rannem vozraste, chem v srednem v populyatsii. Nasleduemye mutatsii v gene retseptora lipoproteinov nizkoy plotnosti vyzyvayut snizhenie skorosti udaleniya kholesterin-perenosyashchikh chastits iz krovotoka, privodyat k semeynoy giperkholesterinemii i ateroskleroticheskomu porazheniyu sosudov. Mutatsii v gene raka molochnoy zhelezy BRCA1 obuslovlivayut razvitie onkopatologii u zhenshchin detorodnogo vozrasta. Kakie izmeneniya v DNK vyzyvayut razvitie ateroskleroza i raka v Rossiyskoy populyatsii, pochemu oni spetsifichny dlya nashey strany, kak sleduet provodit' geneticheskoe testirovanie i kakovo ego znachenie dlya profilaktiki ? na eti voprosy otvechaet predlagaemaya kniga, rasskazyvayushchaya o prioritetnykh issledovaniyakh uchenykh iz NII eksperimental'noy meditsiny SZO RAMN, provedennykh v Sankt-Peterburge. Nastoyashchee izdanie vyzovet interes ne tol'ko u spetsialistov, populyatsionnykh genetikov i meditsinskikh genetikov, no i u vdumchivykh kardiologov i onkologov, genetikov i biologov shirokogo profilya, vsekh lits, interesuyushchikhsya mekhanizmami genomnykh zabolevaniy i ikh diagnostiki.