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Neyronal'nyy 7 Nikotinovyy Atsetilkholinovyy Retseptor: Razrabotka Metodov Detektsii S Ispol'zovaniem Antitel I -neyrotoksinov Iz Yadov Zmey Irina Shelukhina Russian edition
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Neyronal'nyy 7 Nikotinovyy Atsetilkholinovyy Retseptor: Razrabotka Metodov Detektsii S Ispol'zovaniem Antitel I -neyrotoksinov Iz Yadov Zmey
Irina Shelukhina
Gomopentamernyy ?7 podtip nikotinovykh atsetilkholinovykh retseptorov (nAKhR) chrezvychayno shiroko rasprostranen v organizme cheloveka. Dannomu retseptoru otvodyat vazhnuyu rol' pri shizofrenii, boleznyakh Al'tsgeymera i Parkinsona. Kak dlya diagnostiki, tak i dlya issledovaniya mekhanizmov vozniknoveniya i protekaniya zabolevaniy ochevidna neobkhodimost' razrabotki nadezhnykh metodov detektsii ?7 nAKhR. V nastoyashchem issledovanii provedeno kompleksnoe testirovanie spetsifichnosti nabora antitel i pokazana vozmozhnost' ikh ispol'zovaniya dlya rabot s rekombinantnymi ?7 nAKhR. Dlya obnaruzheniya prirodnykh ?7 nAKhR bolee effektivnymi instrumentami okazalis' ?-neyrotoksiny iz yadov zmey ? spetsificheskie blokatory nAKhR. S ispol'zovaniem ikh fluorestsentnykh i biotinilirovannykh proizvodnykh byli razrabotany novye vysokochuvstvitel'nye biokhimicheskie i gistokhimicheskie podkhody dlya detektsii ?7 nAKhR v tkanyakh zhivotnykh. Predlozhennyy gistokhimicheskiy metod v kombinatsii s dopolnitel'nymi markerami byl uspeshno ispol'zovan dlya ustanovleniya ekspressii i transporta ?7 nAKhR pervichnymi afferentnymi neyronami, otvetstvennymi za vospriyatie bolevykh oshchushcheniy.
| Media | Books Paperback Book (Book with soft cover and glued back) |
| Released | July 14, 2011 |
| ISBN13 | 9783845425962 |
| Publishers | LAP LAMBERT Academic Publishing |
| Pages | 144 |
| Dimensions | 150 × 8 × 226 mm · 233 g |
| Language | German |