Michael Chan

Characterization of Novel Metalloprotein Sensors and Carboxypeptidases: Biochemical and Structural Characterization of a Novel Metalloprotein Sensor and Two M32 Carboxypeptidases Michael Chan

The focus of this research was the characterization of three metallroteins. The characterization was based on the information obtained from their structures and biochemical data obtained from in-vitro and in-vivo experiments. The structures of the three proteins studied were obtained by x-ray crystallography. The first protein studied was the hemerythrin-like domain from the Desulfovibrio vulgaris chemoreceptor H, DcrH-Hr. The second protein was the Bacillus subtilis M32 carboxypeptidase, BsuCP. And the third protein was one of the M32 carboxypeptidases from Leishmania major, LmaCP.