Elena Mikhalenko

Geneticheskie Kriterii Predraspolozhennosti K Raku Legkogo: Molekulyarno-geneticheskiy I Tsitogeneticheskiy Analiz U Bol'nykh Rakom Legkogo Elena Mikhalenko Russian edition

V bol'shinstve razvitykh stran mira rak legkogo yavlyaetsya naibolee rasprostranennym onkologicheskim zabolevaniem: po urovnyu zabolevaemosti on zanimaet pervoe mesto u muzhchin; sushchestvuet tendentsiya k rostu zabolevaemosti u zhenshchin. Ezhegodno v mire registriruetsya bolee 1 mln. novykh sluchaev RL. Ekonomicheskie i sotsial'nye posledstviya ustoychivogo rosta zabolevaemosti i smertnosti delayut aktual'nym razrabotku i sovershenstvovanie metodov ranney diagnostiki i prognoza techeniya raka legkogo. Izuchenie polimorfizma genov fermentov biotransformatsii ksenobiotikov, uchastvuyushchikh v metabolizme kantserogennykh veshchestv, i genov faktorov rosta, igrayushchikh klyuchevuyu rol' v angiogeneze, predstavlyaet nesomnennyy interes v opredelenii geneticheskoy predraspolozhennosti zhiteley Belarusi k vozniknoveniyu RL. Tsitogeneticheskie metody issledovaniya do sikh por yavlyayutsya vedushchimi pri provedenii geneticheskogo testirovaniya, skrininga i monitoringa populyatsiy cheloveka, podvergayushchikhsya vozdeystviyu razlichnykh ekologicheskikh faktorov. Predlagaemyy metod interfaznogo analiza aberratsiy khromosom pozvolyaet otsenit' temp mutatsionnogo protsessa i kletochno-letal'nogo effekta v lyuboy delyashcheysya v organizme kletochnoy populyatsii.