Elena Beloglazkina

Novye Proizvodnye 2-tiogidantoinov: Sintez Ligandov, Ikh Koordinatsionnykh Soedineniy Medi (Ii), Fiziko-khimicheskie I Biologicheskie Issledovaniya Elena Beloglazkina Russian edition

Kompleksy perekhodnykh metallov s ligandami na osnove 2-tioksotetragidro-4N-imidazol-4-onov (2-tiogidantoinov) interesny s tochki zreniya ikh biologicheskoy aktivnosti. Dannye soedineniya ispol'zuyutsya v meditsine v kachestve protivorakovykh, antibakterial'nykh, protivomutatsionnykh, antivirusnykh preparatov, preparatov protiv virusa immunodefitsita, protiv zabolevaniy shchitovidnoy zhelezy, tuberkuleza. Pri vvedenii v polozhenie 5 tiogidantoinovogo tsikla zamestiteley, soderzhashchikh razlichnye donornye atomy, znachitel'no rasshiryayutsya vozmozhnosti sinteza koordinatsionnykh soedineniy na osnove etikh organicheskikh ligandov. Byli razrabotany sinteticheskie podkhody k koordinatsionnym soedineniyam medi na osnove proizvodnykh 2-tiogidantoinov, soderzhashchikh v 3-m polozhenii funktsional'nye gruppirovki razlichnoy prirody, a takzhe proveden sintez serii ligandov 2-tioksotetragidro-4N-imidazol-4-onov. Na osnovanii ikh geometricheskogo stroeniya, a takzhe elektronnykh effektov imeyushchikhsya v nikh zamestiteley bylo pokazano, chto koordinatsionnye soedineniya medi na osnove 2-tiogidantoinov yavlyayutsya effektivnymi ingibitorami fermenta telomeraza.