Aleksandr Sergeevich Potapov

Neinvazivnaya Diagnostika Fibroza I Tsirroza Pecheni V Pediatrii: Syvorotochnye Markery Fibrozirovaniya Pri Khronicheskikh Boleznyakh Pecheni U Detey Aleksandr Sergeevich Potapov Russian edition

Techenie khronicheskikh bolezney pecheni sopryazheno s vysokim riskom razvitiya fibroticheskikh izmeneniy pechenochnoy parenkhimy razlichnoy stepeni vyrazhennosti. Konechnoy stadiey fibroza pecheni yavlyaetsya tsirroz, pri dekompensatsii kotorogo provoditsya transplantatsiya organa. V svyazi s etim chrezvychayno vazhna rannyaya diagnostika fibrozirovaniya pecheni, chto osobenno aktual'no v pediatricheskoy praktike. Primenenie punktsionnoy biopsii pecheni u detey ogranicheno vvidu invazivnosti etoy protsedury, imeyushchey ryad protivopokazaniy i trebuyushchey sootvetstvuyushchey kvalifikatsii personala. Poetomu ves'ma perspektivnym predstavlyaetsya poisk neinvazivnykh pokazateley, pozvolyayushchikh opredelit' vyrazhennost' skleroticheskikh izmeneniy v pecheni. V nastoyashchey knige predstavleny dannye ob osobennostyakh izmeneniy syvorotochnykh markerov (gialuronovaya kislota, kollagen IV tipa, matriksnye metalloproteinazy-2 i 9, tkanevoy ingibitor metalloproteinaz-1, transformiruyushchiy faktor rosta-beta1) v zavisimosti ot stadii fibroza pecheni u detey s razlichnymi, v tom chisle redkimi formami ee patologii.